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high molecular weight poly i c invivogen tlrl pic low molecular weight  (InvivoGen)


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    InvivoGen high molecular weight poly i c invivogen tlrl pic low molecular weight
    High Molecular Weight Poly I C Invivogen Tlrl Pic Low Molecular Weight, supplied by InvivoGen, used in various techniques. Bioz Stars score: 98/100, based on 4917 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/high+molecular+weight+poly+i+c/Poly/pm41861786-246-24-28
    Average 98 stars, based on 4917 article reviews
    high molecular weight poly i c invivogen tlrl pic low molecular weight - by Bioz Stars, 2026-09
    98/100 stars

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    High Molecular Weight:

    Article Title: Reducing the impact of HaHV-1 in Australian abalone: The role of age and immune priming.
    Article Snippet: .. High molecular weight poly(I:C) (InvivoGen, Cat: tlrl-pic-5) was made up in endotoxin free water (1 mg/mL) as per the manufacturer’s instructions and stored at − 20 0C until use. ..

    Article Title: Examining the effect of transgenerational immune priming against HaHV-1 in the abalone
    Article Snippet: .. High molecular weight poly (I:C) (InvivoGen, Cat: tlrl-pic-5) was made up in endotoxin-free water (1 mg/mL) as per the manufacturer's instructions and stored at − 20◦ C until use. ..

    Article Title: SIFD-associated TRNT1 deficiency unveils importance of TSPO during macrophage antibacterial and antiviral responses
    Article Snippet: .. LPS (Cat#: TLRL-EKLPS) and high molecular weight Poly (I:C) (Cat#: TLRL-PIC) were purchased from InvivoGen. .. Antimycin A (AA) (Cat#: A8674), rotenone (ROT) (Cat#: R8875), oligomycin (Oligo) (Cat#: O4876) and carbonyl cyanide-p-trifluoromethoxyphenylhydrazone (FCCP) (Cat#: C2920) were acquired from Sigma-Aldrich.

    Article Title: Enhancing cDC1-mediated anti-tumor immunity limits tumor progression and potentiates anti-PD-1 therapy in intrahepatic cholangiocarcinoma
    Article Snippet: C57BL/6 mice were injected intraperitoneally with 30μg active recombinant mouse Flt3L protein (RP01058, ABclonal Technology) dissolved in 100μL PBS or control PBS for 9 consecutive days. .. High molecular weight poly(I:C) (InvivoGen) was injected intraperitoneally for AKT/YAP murine iCCAs (200μg/dose in 100μl PBS), or intratumorally (50μg/dose in 30μl PBS) for mIC-23 subcutaneous tumor injection models on day 5 and 9 after Flt3L administration. .. For anti-PD-1 combination therapy, mice (n=5/group) were treated intraperitoneally every 3 days with 10 mg/kg anti-PD-1 monoclonal antibody (BioXCell, BE0146) or isotype control antibody (BioXCell, BE0089).

    Article Title: ZNFX1 uses two-component ubiquitin circuitry to quarantine viral RNA.
    Article Snippet: Resultant RNA from the two PRKAA2 templates and the provided Fluc Control Template (1.8 kb) was purified using the Monarch RNA cleanup kit (T2030S; NEB) and quantified by nanodrop, producing three ssRNA species: PRKAA2-PRKAB2-PRKAG1 mRNA in tandem (ssRNAPRKAA2-L), PRKAA2 mRNA only (ssRNAPRKAA2-S), and the Fluc control mRNA (ssRNAFluc). .. All other nucleic acids used in the study were purchased from Invivogen, including: high-molecular weight poly(I:C) (#tlrl-pic), low molecular weight poly(I:C) (#tlrlpicw), fluorescein-labelled poly(I:C) (#tlrl-picf), rhodamine-labelled poly(I:C) (#tlrl-picr), biotin-labelled poly(I:C) (#tlrl-picb), and poly(dA:dT) (#tlrl-patn). ..

    Injection:

    Article Title: Enhancing cDC1-mediated anti-tumor immunity limits tumor progression and potentiates anti-PD-1 therapy in intrahepatic cholangiocarcinoma
    Article Snippet: C57BL/6 mice were injected intraperitoneally with 30μg active recombinant mouse Flt3L protein (RP01058, ABclonal Technology) dissolved in 100μL PBS or control PBS for 9 consecutive days. .. High molecular weight poly(I:C) (InvivoGen) was injected intraperitoneally for AKT/YAP murine iCCAs (200μg/dose in 100μl PBS), or intratumorally (50μg/dose in 30μl PBS) for mIC-23 subcutaneous tumor injection models on day 5 and 9 after Flt3L administration. .. For anti-PD-1 combination therapy, mice (n=5/group) were treated intraperitoneally every 3 days with 10 mg/kg anti-PD-1 monoclonal antibody (BioXCell, BE0146) or isotype control antibody (BioXCell, BE0089).

    Article Title: Cathepsin L-dependent positive selection shapes clonal composition and functional fitness of CD4 + T cells.
    Article Snippet: For hock immunization, isoflurane-anesthetized mice were subcutaneously injected with an emulsion of LLO190–201 peptide (NEKYAQAYPNVS, GenScript) in PBS and Freund’s adjuvant (Sigma). .. Systemic immunization was performed by i.v. injection of 50 μg of LLO190–201 peptide and 50 μg of high-molecular-weight poly(I:C) (InvivoGen) in PBS. .. Systemic immunization was performed by i.v. injection of 50 μg of LLO190–201 peptide and 50 μg of high-molecular-weight poly(I:C) (InvivoGen) in PBS.

    Molecular Weight:

    Article Title: ZNFX1 uses two-component ubiquitin circuitry to quarantine viral RNA.
    Article Snippet: Resultant RNA from the two PRKAA2 templates and the provided Fluc Control Template (1.8 kb) was purified using the Monarch RNA cleanup kit (T2030S; NEB) and quantified by nanodrop, producing three ssRNA species: PRKAA2-PRKAB2-PRKAG1 mRNA in tandem (ssRNAPRKAA2-L), PRKAA2 mRNA only (ssRNAPRKAA2-S), and the Fluc control mRNA (ssRNAFluc). .. All other nucleic acids used in the study were purchased from Invivogen, including: high-molecular weight poly(I:C) (#tlrl-pic), low molecular weight poly(I:C) (#tlrlpicw), fluorescein-labelled poly(I:C) (#tlrl-picf), rhodamine-labelled poly(I:C) (#tlrl-picr), biotin-labelled poly(I:C) (#tlrl-picb), and poly(dA:dT) (#tlrl-patn). ..



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    A Timeline for mating and treatment of human STAT2 knock-in (hSTAT2 KI) mice with high molecular weight polyinosinic-polycytidylic acid <t>(HMW</t> <t>poly(I:C)).</t> Created in BioRender. Jurado, K. (2025) https://BioRender.com/eegilr9 . B Serum IL-6 levels in PBS- and HMW Poly(I:C)-treated dams at 6 h post-injection as determined via ELISA. n = 3 dams per group. Statistical analysis performed via ordinary two-way ANOVA, **p < 0.01, ns= not significant (From left, p = >0.9999, 0.0013, 0.0011, 0.9896). Data presented as mean values ± SD. C Proportion of fetuses exhibiting healthy, early resorption, or total resorption phenotypes at E13.5 in PBS- and HMW Poly(I:C)-treated dams. Graph displays total number of fetuses from 3-4 litters per condition. D Representative images depicting fetal outcomes at E13.5. Phenotypes were determined for each fetus based on gross morphology and tissue integrity, as described in methods. E Timeline for mating and infection of hSTAT2 KI mice, as described in methods. Created in BioRender. Jurado, K. (2025) https://BioRender.com/m1xcoc2 . F Proportion of fetuses exhibiting healthy, early resorption, or total resorption phenotypes at E13.5 in PBS- and ZIKV-infected dams. Fetal outcomes were evaluated in 3 independent litters for all conditions except ZIKV-infected IL27RA −/− dams, for which 4 independent litters were evaluated. Graph displays total number of fetuses per condition. G–I ZIKV burdens at E13.5 as determined via quantitative RT-PCR. G Combined ZIKV burden of one matching fetus and placenta, normalized to combined tissue weight. Shape of data point represents observed fetal phenotype. Total number of fetal/placental units per condition plotted (see 4 F ). Statistical analysis performed via Kruskal-Wallis ANOVA, ***p < 0.001, ns=not significant (From left, p = >0.9999, 0.0006). H Left: Fetal ZIKV burdens, normalized to fetus weights. Viral burdens for subset of fetuses exhibiting “healthy” phenotypes plotted (Isotype n = 24, α-IL-27 n = 16, IL27RA −/− n = 28). Right: Placental ZIKV burdens, normalized to placental weights. Viral burdens of placentas matched to fetuses with “healthy” phenotypes plotted (Isotype n = 24, α-IL-27 n = 16, IL27RA −/− n = 28). Statistical analysis performed via Kruskal-Wallis ANOVA, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, ns=not significant (Fetal from left, p = >0.9999, 0.0374; Placental from left, p = 0.0378, <0.0001). I Maternal serum ZIKV burdens, normalized to serum weight. n = 3 dams for Isotype and α-IL-27-treated groups, n = 4 IL27RA −/− dams. Not significant via Kruskal-Wallis ANOVA.
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    A Timeline for mating and treatment of human STAT2 knock-in (hSTAT2 KI) mice with high molecular weight polyinosinic-polycytidylic acid (HMW poly(I:C)). Created in BioRender. Jurado, K. (2025) https://BioRender.com/eegilr9 . B Serum IL-6 levels in PBS- and HMW Poly(I:C)-treated dams at 6 h post-injection as determined via ELISA. n = 3 dams per group. Statistical analysis performed via ordinary two-way ANOVA, **p < 0.01, ns= not significant (From left, p = >0.9999, 0.0013, 0.0011, 0.9896). Data presented as mean values ± SD. C Proportion of fetuses exhibiting healthy, early resorption, or total resorption phenotypes at E13.5 in PBS- and HMW Poly(I:C)-treated dams. Graph displays total number of fetuses from 3-4 litters per condition. D Representative images depicting fetal outcomes at E13.5. Phenotypes were determined for each fetus based on gross morphology and tissue integrity, as described in methods. E Timeline for mating and infection of hSTAT2 KI mice, as described in methods. Created in BioRender. Jurado, K. (2025) https://BioRender.com/m1xcoc2 . F Proportion of fetuses exhibiting healthy, early resorption, or total resorption phenotypes at E13.5 in PBS- and ZIKV-infected dams. Fetal outcomes were evaluated in 3 independent litters for all conditions except ZIKV-infected IL27RA −/− dams, for which 4 independent litters were evaluated. Graph displays total number of fetuses per condition. G–I ZIKV burdens at E13.5 as determined via quantitative RT-PCR. G Combined ZIKV burden of one matching fetus and placenta, normalized to combined tissue weight. Shape of data point represents observed fetal phenotype. Total number of fetal/placental units per condition plotted (see 4 F ). Statistical analysis performed via Kruskal-Wallis ANOVA, ***p < 0.001, ns=not significant (From left, p = >0.9999, 0.0006). H Left: Fetal ZIKV burdens, normalized to fetus weights. Viral burdens for subset of fetuses exhibiting “healthy” phenotypes plotted (Isotype n = 24, α-IL-27 n = 16, IL27RA −/− n = 28). Right: Placental ZIKV burdens, normalized to placental weights. Viral burdens of placentas matched to fetuses with “healthy” phenotypes plotted (Isotype n = 24, α-IL-27 n = 16, IL27RA −/− n = 28). Statistical analysis performed via Kruskal-Wallis ANOVA, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, ns=not significant (Fetal from left, p = >0.9999, 0.0374; Placental from left, p = 0.0378, <0.0001). I Maternal serum ZIKV burdens, normalized to serum weight. n = 3 dams for Isotype and α-IL-27-treated groups, n = 4 IL27RA −/− dams. Not significant via Kruskal-Wallis ANOVA.

    Journal: Nature Communications

    Article Title: Interleukin-27 is antiviral against Zika virus at the maternal-fetal interface

    doi: 10.1038/s41467-025-67378-0

    Figure Lengend Snippet: A Timeline for mating and treatment of human STAT2 knock-in (hSTAT2 KI) mice with high molecular weight polyinosinic-polycytidylic acid (HMW poly(I:C)). Created in BioRender. Jurado, K. (2025) https://BioRender.com/eegilr9 . B Serum IL-6 levels in PBS- and HMW Poly(I:C)-treated dams at 6 h post-injection as determined via ELISA. n = 3 dams per group. Statistical analysis performed via ordinary two-way ANOVA, **p < 0.01, ns= not significant (From left, p = >0.9999, 0.0013, 0.0011, 0.9896). Data presented as mean values ± SD. C Proportion of fetuses exhibiting healthy, early resorption, or total resorption phenotypes at E13.5 in PBS- and HMW Poly(I:C)-treated dams. Graph displays total number of fetuses from 3-4 litters per condition. D Representative images depicting fetal outcomes at E13.5. Phenotypes were determined for each fetus based on gross morphology and tissue integrity, as described in methods. E Timeline for mating and infection of hSTAT2 KI mice, as described in methods. Created in BioRender. Jurado, K. (2025) https://BioRender.com/m1xcoc2 . F Proportion of fetuses exhibiting healthy, early resorption, or total resorption phenotypes at E13.5 in PBS- and ZIKV-infected dams. Fetal outcomes were evaluated in 3 independent litters for all conditions except ZIKV-infected IL27RA −/− dams, for which 4 independent litters were evaluated. Graph displays total number of fetuses per condition. G–I ZIKV burdens at E13.5 as determined via quantitative RT-PCR. G Combined ZIKV burden of one matching fetus and placenta, normalized to combined tissue weight. Shape of data point represents observed fetal phenotype. Total number of fetal/placental units per condition plotted (see 4 F ). Statistical analysis performed via Kruskal-Wallis ANOVA, ***p < 0.001, ns=not significant (From left, p = >0.9999, 0.0006). H Left: Fetal ZIKV burdens, normalized to fetus weights. Viral burdens for subset of fetuses exhibiting “healthy” phenotypes plotted (Isotype n = 24, α-IL-27 n = 16, IL27RA −/− n = 28). Right: Placental ZIKV burdens, normalized to placental weights. Viral burdens of placentas matched to fetuses with “healthy” phenotypes plotted (Isotype n = 24, α-IL-27 n = 16, IL27RA −/− n = 28). Statistical analysis performed via Kruskal-Wallis ANOVA, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, ns=not significant (Fetal from left, p = >0.9999, 0.0374; Placental from left, p = 0.0378, <0.0001). I Maternal serum ZIKV burdens, normalized to serum weight. n = 3 dams for Isotype and α-IL-27-treated groups, n = 4 IL27RA −/− dams. Not significant via Kruskal-Wallis ANOVA.

    Article Snippet: To mimic immune activation during viral infection, High Molecular Weight (HMW) Vaccigrade Poly(I:C) (Invivogen, vac-pic) was delivered to pregnant mice at E6.5 via intraperitoneal injection at 20 mg/kg.

    Techniques: Knock-In, High Molecular Weight, Injection, Enzyme-linked Immunosorbent Assay, Infection, Quantitative RT-PCR